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Liberal transfusion af røde donorblodceller kan øge mortaliteten

Opbevaring af røde donorblodceller
Forfatter(e)
Hans-Christian Pommergaard1, Astrid Nørgaard2, Jakob Burcharth1, Trine Stissing2 & Jacob Rosenberg1. 1) Gastroenheden, Kirurgisk Sektion, Herlev Hospital 2) Transfusionsmedicinsk Enhed, Region Hovedstadens Blodbank, Rigshospitalet Ugeskr Læger 2014;176:V06130398
Reference: 
Ugeskr Læger 2014;176:V06130398
Blad nummer: 
Sidetal: 
630-633
Liberal red blood cell transfusion may increase mortality
In addition to the known adverse effects of red blood cell transfusion, evidence suggests that transfusion with allogeneic red blood cells in itself may increase mortality, risk of infection and even cancer recurrence rates. Among possible mechanisms to explain this effect are transfusion-related immune modulation and storage lesions. However, anaemia may also increase mortality and the risk of anaemia should be balanced against the risks of transfusion. Further properly designed and powered studies are needed to clarify the beneficial and harmful effects of red blood cell transfusion in well-defined patient categories.
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