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Antistoffer hos patienter med kronisk inflammatorisk demyeliniserende polyneuropati

Abdullahi Ahmed Mohamed1, Thomas Krøigård1, Thomas Agerbo Gaist1, Lars Kjøbsted Markvardsen2, Søren Sindrup1, 3, Henning Andersen2 & Morten Blaabjerg1, 3
1) Neurologisk Afdeling, Odense Universitetshospital2) Neurologisk Afdeling, Aarhus Universitetshospital3) Klinisk Institut, Syddansk Universitet

Ugeskr Læger 2018;180:V08180526
Ugeskr Læger 2018;180:V08180526

Abdullahi Mohamed, Thomas Krøigård, Thomas Agerbo Gaist, Lars Kjøbsted Markvardsen, Søren Sindrup, Henning Andersen & Morten Blaabjerg:

Antibodies in patients with chronic inflammatory demyelinating polyneuropathy

Ugeskr Læger 2018;180:V08180526

Recent studies have identified specific immunoglobulin (Ig) G4 antibodies against the paranodal proteins neurofascin 155 and contactin 1 in subgroups of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). These patients present with distinct clinical phenotypes and poor response to first-line therapy with intravenous Ig. Detection of these antibodies in patients with CIDP has diagnostic, prognostic, and therapeutic implications. This review summarises the current knowledge on clinical characteristics, pathogenesis and treatment of these patients.

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