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Anvendelse af thiaziddiuretika i hypertensions-behandlingen – en gennemgang af et Cochranereview

Manneken Pis – diuretika øger saltudskillelsen.
Knud Rasmussen Medicinsk Afdeling, Roskilde Sygehus Ugeskr Læger 2015;177:V12140757
Ugeskr Læger 2015;177:V12140757
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Thiazide diuretics in the treatment of hypertensive patients
This Cochrane review had the objectives to determine the dose-related decrease in blood pressure due to thiazide diuretics compared with placebo control in the treatment of hypertensive patients. Hydrochlorothiazide has a dose-related blood pressure-lowering effect over the dose range 6.25, 12.5, 25 and 50 mg/day of 4/2, 6/3, 8/3 and 11/5 mmHg, respectively. This exceeds the mean 3 mmHg reduction achieved by angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers as shown in other Cochrane reviews, which have compared these antihypertensive drugs with placebo having used similar inclusion/exclusion criteria.
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