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Arbejdsbetinget astma udløst af maleinsyreanhydrid

Forfatter(e)
Martin Rune Hansen1, Flemming Lander2, Tina Skjold3, 4, Henrik Albert Kolstad4, 5, Hans Jürgen Hoffmann3, 4 & Vivi Schlünssen1, 4 1) Sektion for Miljø, Arbejde og Sundhed, Institut for Folkesundhed, Aarhus Universitet 2) Arbejdsmedicinsk Klinik, Dansk Ramazzini Center, Regionshospitalet Herning 3) Lungemedicinsk Afdeling, Aarhus Universitetshospital 4) Allergicenter Vest, Aarhus Universitetshospital 5) Arbejdsmedicinsk Klinik, Dansk Ramazzini Center, Aarhus Universitetshospital Ugeskr Læger 2014;176:V04140237
Reference: 
Ugeskr Læger 2014;176:V04140237
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2-3
Occupational asthma caused by maleic anhydride
Organic acid anhydrides (OAA) are widely used in the chemical industry. They are irritants and can cause sensitization and asthma. We describe the first documented case of occupational asthma caused by the OAA maleic anhydride (MA) in the production of insecticides. A 60-year-old man developed work-related respiratory symptoms after eight years of intermittent exposure to MA. Peak expiratory flow measurements showed greater variance on work days than on days off. Both a basophilic activation test and determination of the MA-specific IgE level in serum showed sensitization to MA.
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