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Fluorescensvejledt fjernelse af cerebrale glioblastomer

Forfatter(e)
Rasmus Würgler Hansen, Frantz Rom Poulsen, Mette Schulz & Christian Bonde Pedersen Neurokirurgisk Afdeling, Odense
Universitetshospital

Ugeskr Læger 2019;181:V04180265
Reference: 
Ugeskr Læger 2019;181:V04180265
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Rasmus Würgler Hansen, Frantz Rom Poulsen, Mette Schulz & Christian Bonde Pedersen:

Fluorescence-guided resection of cerebral tumours

Ugeskr Læger 2019;181:V04180265

Traditionally, cerebral tumours were operated through a microscope under white light. In recent years, MRI used for peroperative navigation and techniques of colour-visualising the malignant tissue have made resection more precise, radical and safe. However, 5-aminolevulinic acid has been shown to increase neurological deficit due to supramarginal resection. Two widely used substances for tumour-visualisation are 5-aminolevulinic and sodium fluorescein. Both have shown an increased rate of resection compared with white light, but the evidence towards 5-aminolevulinic acid is strongest.

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