Hæmning af proteinet PCSK9 er en lovende behandling af hyperkolesterolæmi og forebyggelse af hjerte-kar-sygdom
Ugeskr Læger 2015;177:V11140582
Inhibition of the protein PCSK9 is a promising target in the prevention of cardiovascular disease
Recent research in genetics has revealed that PCSK9 – which codes for proprotein convertase subtilisin/kexin type 9 (PCSK9) – plays a major role in cholesterol regulatory pathways. Normal genetic variations in PCSK9 have a great impact on low-density lipoprotein cholesterol levels and hence the risk of cardio-vascular disease. This has led to huge efforts in inhibiting PCSK9. Recent clinical phase II trials with monoclonal antibodies against PCSK9 have shown great results for lowering low-density lipoprotein cholesterol levels making the inhibition of PCSK9 a promising target in the prevention of cardiovascular disease.