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Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

Forfatter(e)
Jeanette K. Petersen1, 2, David Scheie3, Henning B. Boldt1, 2 Benedicte P. Ulhøi4, Marianne S. Ettrup5 & Bjarne W. Kristensen1, 2
1) Afdeling for Klinisk Patologi, Odense Universitetshospital 2) Klinisk Institut, Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet 3) Patologiafdelingen, Rigshospitalet 4) Patologi, Aarhus Universitetshospital 5) Patologisk Institut, Aalborg Universitetshospital

Ugeskr Læger 2019;181:V07180509

Reference: 
Ugeskr Læger 2019;181:V07180509

Jeanette K. Petersen, David Scheie, Henning B. Boldt, Benedicte P. Ulhøi,
Marianne S. Ettrup & Bjarne W. Kristensen:

Integrated diagnostics of brain tumours based on histological and molecular features

Ugeskr Læger 2019;181:V07180509

Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A considerable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute “integrated diagnoses”. The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.

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