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Præimplantationsgenetisk testning for aneuploidi

Forfatter(e)
Viktoria Holmqvist1, Laura Kirstine Soenderberg Roos2, Kristin Ros Kjartansdottir2, Morten Dunø2, Morten Rønn Petersen1, Christina Hnida3, Inge Søkilde Pedersen4, 5, Anja Ernst4, Christian Liebst Frisk Toft4, Tue Diemer6, Hans Jakob Ingerslev3, Anja Pinborg1 & Kristine Løssl1
1) Fertilitetsklinikken, Juliane Marie Centret, Rigshospitalet 2) Klinisk Genetisk Klinik, Rigshospitalet 3) Fertilitetsklinikken, Aalborg Universitetshospital 4) Molekylær Diagnostik, Aalborg Universitetshospital 5) Klinisk Institut, Aalborg Universitet 6) Klinisk Genetisk Afdeling, Aalborg Universitetshospital

Ugeskr Læger 2019;181:V12180849

Reference: 
Ugeskr Læger 2019;181:V12180849

Viktoria Holmqvist, Laura Kirstine Soenderberg Roos, Kristin Ros Kjartansdottir,
Morten Dunø, Morten Rønn Petersen, Christina Hnida, Inge Søkilde Pedersen,
Anja Ernst, Christian Liebst Frisk Toft, Tue Diemer, Hans Jakob Ingerslev,
Anja Pinborg & Kristine Løssl:

Preimplantation genetic testing for aneuploidy

Ugeskr Læger 2019;181:V12180849

This review summarises the current knowledge on preimplantation genetic testing for aneuploidy (PGT-A). Selection and transfer of euploid embryos aim to improve live birth rate (LBR) per embryo transfer, but fluorescence in situ hybridisation-based PGT-A and biopsy of cleavage stage embryos in the 2000s was a disappointment, as studies revealed a reduced LBR. Today, PGT-A includes comprehensive chromosome screening primarily of blastocyst biopsies. The benefit of PGT-A is highly debated: some suggest improved treatment outcome, while others claim, that the procedure is not cost-effective.

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