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Stiff person syndrome er fortsat en vanskelig og overset diagnose

Forfatter(e)
Mette Scheller Nissen1,2, Jonatan Forsberg1, Matthias Bode1 & Morten Blaabjerg1,2
1) Neurologisk Afdeling, Odense Universitets-hospital 2) Klinisk Institut, Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet

Ugeskr Læger 2019;181:V03190166
Reference: 
Ugeskr Læger 2019;181:V03190166

Mette Scheller Nissen, Jonatan Forsberg, Matthias Bode &
Morten Blaabjerg:

Stiff person syndrome: still a difficult and overlooked diagnosis

Ugeskr Læger 2019;181:V03190166

We present a case of stiff person syndrome (SPS) with a description of the diagnostic challenges and a discussion of the implication of novel antibodies. SPS is a rare neurological disorder presenting with severe rigidity, muscle spasms and impaired gait function, and diagnosis is often delayed due to low awareness. SPS is classically associated with antibodies directed against glutamic acid decarboxylase or amphiphysin. However, recent advances have contributed to our understanding because of detection of several new antibodies, which cause SPS, mostly with additional neurological/systemic manifestations.

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