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Natural history of antibodies against SARS-CoV-2 in Danish hospital workers during the first wave of the pandemic

The study of Johannesen et al in the May issue of the Danish Medical Journal takes us back to the pre-vaccine era during the first wave of the COVID-19 pandemic. The authors investigated the natural history of anti-SARS-CoV-2 antibodies in 379 healthcare workers in two Danish acute hospitals from March 2020 until December 2020. They report that 5.3% of the participants had antibodies at the inclusion and that 25% of the seropositive participants reverted during follow-up, which yielded a calculated probability of having detectable antibodies among former seropositive participants of 72.2% after 39 weeks. The authors suggest further analyses of larger cohorts to explore individual factors related to the duration of detectable antibodies.

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Prevalence and duration of anti-SARS-CoV-2 antibodies in healthcare workers
Caroline Klint Johannesen, Gry St. Martin, Maria Elisabeth Lendorf et al


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