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Optimal choice of serological test for diagnosis of rheumatoid arthritis in primary care

Musculoskeletal complaints are common in primary care and although only few patients will suffer from rheumatoid arthritis (RA), this diagnosis should not be overlooked. Serological markers play an important role in the diagnostic process together with anamnesis, clinical examination and imaging. The present study investigates the sensitivity and specificity of two common RA serological tests (ACPA and IgM RF) when RA is suspected in primary care.
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The authors conclude that in this setting ACPA is a better choice with a higher positive predicted value.

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Use and utility of serologic tests for rheumatoid arthritis in primary care
Helene Broch Tenstad, Anna Christine Nilsson, Christoffer Dalsgaard Dellgren et al

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