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Autoimmun hepatitis forudgået af hepatitis A-infektion

Forfatter(e)
Anne Grave1, Jacob Juel1, Mogens Vyberg2, 3, Søren Schou Olesen1 & Jesper Bach Hansen1 1) Mech-Sense, Medicinsk Gastroenterologisk Afdeling, Aalborg Universitetshospital 2) Patologisk Institut, Aalborg Universitetshospital 3) Klinisk Institut, Aalborg Universitet Ugeskr Læger 2015;177:V12140669
Reference: 
Ugeskr Læger 2015;177:V12140669
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2-3
Autoimmune hepatitis preceded by hepatitis A
Autoimmune hepatitis is characterized by unresolving inflam­mation and fibrosis of the liver, which untreated may lead to cirrhosis. The pathogenesis remains unclear and reflects a complex interaction between autoantigens, genetic predi­s­position, triggering factors and immune regulation. In rare cases, acute hepatitis A has been suspected as a triggering factor. We describe a case of a 66-year-old woman who two months after a resolving acute hepatitis A presented with fatigue, pale stools and elevated levels of transaminases. A liver biopsy showed histological changes compatible with autoim­mune hepatitis.
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