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Hyperfibrinolyse som årsag til blødning og øget mortalitet hos traumepatienter

Anne Juul Wikkelsø, Arash Afshari, Jakob Stensballe & Pär I. Johansson Blodbanken Region Hovedstaden
Ugeskr Læger 2011;173(18):1284-1287
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Summary Hyperfibrinolysis as the cause of haemorrhage and increased mortality in trauma patients Ugeskr Læger 2011;173(18):1284-1287 Trauma-associated coagulopathies are at times present upon arrival at the emergency department. Hyperfibrinolysis is a condition in which the natural ability to dissolve blood clots is pathologically enhanced. It is present in 2-8% of trauma patients and associated with shock and increased mortality. Hyperfibrinolysis is easily detected by thromboelastography. The condition is treated with antifibrinolytics such as tranexamic acid - where as transfusion with blood products is inefficient. This article explores the mechanisms and diagnostics of hyperfibrinolysis in trauma patients and the relevant treatment options.
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