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Kolesterolsænkende behandling med PCSK9-inhibitorer

Michael E. Røder1, Per Hildebrandt2, Heidi Storgaard3 & Merete Heitmann4 1) Steno Diabetes Center Odense, Odense Universitetshospital2) Frederiksberg Hjerteklinik3) Steno Diabetes Center Copenhagen4) Kardiologisk Afdeling, Bispebjerg Hospital

Ugeskr Læger 2018;180:V11170831
Ugeskr Læger 2018;180:V11170831
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Michael E. Røder, Per Hildebrandt, Heidi Storgaard &
Merete Heitmann:

Cholesterol-lowering treatment with PCSK9-inhibitors

Ugeskr Læger 2018;180:V11170831

Monoclonal antibodies inhibiting proprotein convertase subtilisin-kexin type 9 constitute a new class of lipid-lowering drugs. Currently, evolocumab and alirocumab are marketed. A recent cardiovascular outcome study with evolocumab has shown a cardiovascular (CV) event reduction of 15% in high-risk individuals at very low levels of low-density lipoproteins. The adverse event profile up to two years is mild. Treatment is very costly, and data on CV endpoints are still limited. Treatment is restricted to patients at very high risk of getting CV diseases and on a maximal tolerated statin and ezetimibe treatment in addition to dietary intervention.

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