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Desmoplasiens og pankreatiske stellate cellers betydning ved pancreascancer

Michael Friberg Bruun Nielsen1, Michael Bau Mortensen2 & Sönke Detlefsen1 1) Afdeling for Klinisk Patologi, Odense Universitetshospital 2) G1-sektionen, Kirurgisk Afdeling A, Odense Universitetshospital Ugeskr Læger 2015;177:V01150079
Ugeskr Læger 2015;177:V01150079
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The impact of desmoplasia and pancreatic stellate cells on pancreatic cancer
Pancreatic cancer (PC) has an extremely high mortality with a five-year survival of only 5%. The cancer cells are accom­panied by the desmoplastic stroma produced by cancer-associated fibroblasts (CAFs). Pancreatic stellate cells are the most important source of CAFs. Several studies indicate that the desmoplastic stroma reduces the effect of radio- and chemotherapy, but experimental reduction of desmo­plasia and CAFs leads to more aggressive cancers. Hence, the exact role of desmoplasia in PC remains to be eluci­d­ated, and future studies should also include human pan­crea­tic tissue.
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