Content area

|
|

Desmoplasiens og pankreatiske stellate cellers betydning ved pancreascancer

Forfattere
Michael Friberg Bruun Nielsen1, Michael Bau Mortensen2 & Sönke Detlefsen1 1) Afdeling for Klinisk Patologi, Odense Universitetshospital 2) G1-sektionen, Kirurgisk Afdeling A, Odense Universitetshospital Ugeskr Læger 2015;177:V01150079
Reference: 
Ugeskr Læger 2015;177:V01150079
Blad nummer: 
Sidetal: 
2-5
The impact of desmoplasia and pancreatic stellate cells on pancreatic cancer
Pancreatic cancer (PC) has an extremely high mortality with a five-year survival of only 5%. The cancer cells are accom­panied by the desmoplastic stroma produced by cancer-associated fibroblasts (CAFs). Pancreatic stellate cells are the most important source of CAFs. Several studies indicate that the desmoplastic stroma reduces the effect of radio- and chemotherapy, but experimental reduction of desmo­plasia and CAFs leads to more aggressive cancers. Hence, the exact role of desmoplasia in PC remains to be eluci­d­ated, and future studies should also include human pan­crea­tic tissue.

💬 0 Kommentarer

Du skal være logget ind for at læse denne artikel
Log ind

Right side

af Jens Kibsgaard Riis | 15/08
1 Kommentar
af Camilla Bang | 15/08
3 kommentarer
af Lars Ulrik Gerdes | 14/08
1 Kommentar
af Frede Simonsen | 13/08
1 Kommentar
af Ebbe Bonde Sørensen | 13/08
10 kommentarer
af Birgitte Retbøll | 12/08
20 kommentarer
af Zbigniew Sroczynski | 11/08
1 Kommentar