Content area

|
|

Genetisk HFE-hæmokromatose

Forfatter(e)
Nils T. Milman1, Frank V. Schiødt1, Anders E. Junker2, Karin Magnussen3, Torben Nathan4 & Thomas Damgaard Sandahl5 1) Gastromedicinsk Afsnit, Abdominalcenter K, Bispebjerg Hospital2) Gastroenheden, Medicinsk Sektion, Hvidovre Hospital3) Avdeling Blodbank og Medisinsk Biokjemi, Sykehuset Innlandet, Lillehammer4) Medicinsk Afdeling, Gastroenterologisk Sektion, Sygehus Lillebælt, Vejle5) Afdeling for Lever-, Mave- og Tarmsygdomme, Aarhus Universitetshospital

Ugeskr Læger 2018;180:V09180619
Reference: 
Ugeskr Læger 2018;180:V09180619
Sidetal: 

Nils T. Milman, Frank V. Schiødt, Anders E. Junker,
Karin Magnussen, Torben Nathan & Thomas Damgaard Sandahl:

Genetic HFE-haemochromatosis

Ugeskr Læger 2018;180:V09180619

HFE-haemochromatosis is the most frequent genetic disposition for iron overload in ethnic Danes: 20,000 persons are homozygous for the C282Y mutation. The disorder has a long preclinical phase with increasing body iron overload, and 30% of males will develop clinically overt disease, presenting with symptoms of fatigue, arthralgias, reduced libido, erectile dysfunction, cardiac disease, diabetes and liver disease, later progressing into cirrhosis, cardiomyopathy, pancreatic fibrosis and osteoporosis. Treatment consists of phlebotomies, which in the preclinical and early clinical phases ensure normal survival.

Du skal være logget ind for at læse denne artikel
Log ind

Right side

af Jesper Krarup | 23/03
15 kommentarer
af Astrid Hanna M. Schulze | 23/03
1 Kommentar
af Christian Schlütter | 23/03
10 kommentarer
af Poul Erik Rørbæk | 22/03
29 kommentarer
af Niels Foldager | 19/03
1 Kommentar
af Stig Gerdes | 18/03
4 kommentarer
af Gorm Greisen | 17/03
1 Kommentar
af Lars Erik Larsen | 17/03
5 kommentarer