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Genomet og diabetes

Forfatter(e)
Kristine Højgaard Allin, Torben Hansen & Oluf Borbye Pedersen Novo Nordisk Fondens Metabolismecenter, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet Ugeskr Læger 2014;176:V06140337
Reference: 
Ugeskr Læger 2014;176:V06140337
Blad nummer: 
Sidetal: 
2176-2179
The genome and diabetes
In terms of their genetic architecture monogenic diabetes and type 2 diabetes represent two extremes. Whereas each subtype of monogenic diabetes is caused by one penetrant, rare mutation in a single gene, the genetic susceptibility to type 2 diabetes can be attributed to many low-penetrant variants across the genome. At present, only 10% of the genetic susceptibility to type 2 diabetes can be explained by the hitherto identified 90 genomic loci. Here we briefly review the genetics of monogenic diabetes and type 2 diabetes and outline future directions of research within this field.
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