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Immuncheckpointantistoffer øger overlevelsen for patienter med metastatisk melanom

Kutant melanom. (Foto: Pia Sjøgren).
Forfattere
Louise Elkjær Fløe1, Inge Marie Svane2, Lars Bastholt3 & Henrik Schmidt1 1) Onkologisk Afdeling, Aarhus Universitetshospital 2) Center for Cancer Immunterapi, Herlev Hospital 3) Onkologisk Afdeling, Odense Universitetshospital Ugeskr Læger 2016;178:V01160070
Reference: 
Ugeskr Læger 2016;178:V01160070
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Sidetal: 
2-5
Immune checkpoint antibodies increase survival in patients with metastatic melanoma
The incidence of melanoma is rising and until recently, metastatic melanoma had a poor survival prognosis. Manipulation of two newly discovered immune pathways have shown impressive results. The first is treatment with anti-cytotoxic T-lymphocyte-antigen (CTLA)-4 antibody which blocks the inhibitory receptor CTLA-4. The other is anti-programmed cell death (PD)-1 antibody which blocks the inhibitory receptor PD-1 on T-cells. Thereby, the T-cells are kept activated and able to attack cancer cells.

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