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National guideline til aldersjusteret cut-off for fibrin D-dimerværdi ved diagnostik af venetrombose

Forfatter(e)

Mads Nybo1, 2 & Anne-Mette Hvas3

1) Afdeling for Klinisk Biokemi og Farmakologi, Odense Universitetshospital 2) Dansk Selskab for Trombose og Hæmostase 3) Blodprøver og Biokemi, Aarhus Universitetshospital Ugeskr Læger 2018;180:V10170751

Reference: 
Ugeskr Læger 2018;180:V10170751
Blad nummer: 
Sidetal: 
2-4
A national Danish guideline for age-adjusted fibrin D-dimer cut-off values in the diagnosis of venous thrombosis

Evidence has been gathered that use of an age-adjusted fibrin D-dimer cut-off value for patients above 50 years of age for ruling out deep venous thrombosis is just as safe as using a standard fibrin D-dimer cut-off value. Due to the lower number of false-positive results when using the age-adjusted cut-off values, it is therefore nationally recommended in Denmark that systematic use of a pretest clinical score is supported by fibrin D-dimer measurements using age-adjusted cut-off values for every ten-year interval in patients above 50 years of age, i.e. 0.6 mg/l fibrinogen equivalent units (FEU) for patients being 55-65 years of age, 0.7 mg/l FE/l for patients being 65-75 years and 0.8 mg/l FEU for patients above 75 years of age.

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