Ugeskr Læger 2018;180:V08170584
Psychopathology and diagnosis
Despite 100 years of research schizophrenia remains a scientific challenge. Schizophrenia should be understood as a spectrum of conditions ranging from subclinical manifestations observed in the patients’ relatives over milder forms (schizotypal disorder) to severe psychosis. Recent research indicates that a disturbance of the fundamental structure of selfhood is a generative disorder behind the more manifest and psychotic manifestations. This rediscovery of the original classical insight opens new avenues for differential diagnosis, therapy and research.