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Videnskab / 13. feb 2017

Succesfuld behandling af svær dabigatranoverdosering med idarucizumab hos en patient med nyresvigt

Kasuistik
Dato
13. feb 2017
Forfattere
Christina Gjerlev Poulsen1, Morten Bestle2 & Lene Boesby1 1) Kardiologisk, Nefrologisk og Endokrinologisk Afdeling, Nordsjællands Hospital – Hillerød 2) Anæstesiologisk Afdeling, Nordsjællands Hospital – Hillerød Ugeskr L æger 2017;179:V08160562
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Reference: 
Ugeskr Læger 2017;179:V08160562
Sidetal: 
2-4
Successful treatment of severe dabigatran intoxication with idarucizumab in a patient with acute kidney injury
In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration of idarucizumab induced immediate clinical and paraclinical improvement. Dabigatran should be carefully administrated in patients who have any degree of renal insufficiency. Idarucizumab may be effective in severe bleeding caused by dabigatran.

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