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Tarmmikrobiota og depression

Forfattere
Julie Kristine Knudsen1, 2, 3, Zenia Funch Jensen4, 5, Alice Højer Christensen6, Stig Günther6, Lene Nørby Nielsen7, Peter Leutscher1, 2 & Sidse Arnfred4, 5 1) Center for Klinisk Forskning, Regions-hospital Nordjylland 2) Det Sundhedsvidenskabelige Fakultet, Aalborg Universitet 3) Translational Neuropsychiatry Unit, Aarhus Universitet 4) Psykiatrien Vest, Slagelse, Region Sjælland 5) SUND, Københavns Universitet 6) Aleris-Hamlet, København 7) Fødevareinstituttet, Danmarks Tekniske Universitet Ugeskr Læger 2017;179:V11160854
Reference: 
Ugeskr Læger 2017;179:V11160854
Blad nummer: 
Sidetal: 
2-5
Gut microbiota and depressive symptoms
The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial signalling to the host through metabolic, endocrinal, immunologic and neuronal pathways. Few studies of patients with depression have shown altered microbiota profiles and increased levels of systemic endotoxin, which can be detected by leucocytes and result in expression of cytokines. Studies performed so far have lacked statistical power and provide no causal explanation for the gut-brain hypothesis. Further research into the matter is certainly warranted.

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