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Preoperative pharmacological intervention with potential of reducing delirium in patients with hip fractures

Delirium is a common complication to hip fractures and many cases develop preoperatively. The aetiology is often multifactorial and includes physiological stress, hypovolemia, hypotension, pain, and opioid treatment. Virsøe-Frandsen et al conducted a systematic review to investigate the effect of simple preoperative interventions for the prevention of delirium in patients with hip fractures with the aim to implement resource-sparring treatments for the initial admission phase. The study identified four treatments with a potential to reduce preoperative delirium: methylprednisolone, fascia iliaca block, hypertonic saline and rivastigmine patches. As the studies had a high risk of bias, the authors conclude that these treatments should be investigated further in the preoperative setting in hip fracture patients, either in combination or as single interventions.

Editorial board

5. jul. 2022
1 min.