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Diagnostic packages can be assigned accurately in emergency departments. A multi-centre cohort study

Birgitte Nørgaard1, Christian Backer Mogensen2, 6, Lars Stubbe Teglbjærg3, Mikkel Brabrand4-6 & Annmarie Touborg Lassen5,

1. jun. 2016
14 min.

Faktaboks

Fakta

Patients arrive at emergency departments (EDs) with symptoms and problems rather than diagnoses. However, most existing research is performed using already established diagnoses, typically discharge diagnoses. Therefore, in emergency medicine, there is a need for knowledge of the ED patients’ chief complaints rather than their discharge diagnoses. Besides, a systematic registration of ED patients’ chief complaints can be used as a surveillance tool [1-3] and as a clinical support system in daily clinical practice [4].

In the Region of Southern Denmark (RSD), all five emergency departments have been using a management approach based on chief patient complaints since 2011. This approach includes categorising patients based on chief complaints and assigning them to a proposed diagnostic package specific to each co mplaint category [5, 6]. For each complaint, the diagnostic package describes which clinical information and standard laboratory and other investigations are to be performed: some within the first half hour and some within four hours
after arrival in order to reach an action diagnosis. The symptom-based diagnostic packages were developed based on information from 10,070 patient contacts where the chief complaints were aggregated into 31 categories. Further processing by expert panels resulted in 40 diagnostic packages describing relevant diagnostic actions to be taken within certain time frames [7]. The overall objective of designing these packages was to ensure consistent quality around the clock. The packages were implemented in all five RSD EDs following thorough education of nurses and doctors in each department.

We assume that allocation to the right diagnostic package is associated with higher quality as well as increased effectiveness regarding the patient flow through the ED.

However, an important assumption underlying this argument is that there is an association between diagnostic package and end result (i.e. discharge diagnosis). To validate this assumption, we performed the present study with the aim of describing to which degree the assigned symptom-based diagnostic packages are related to relevant discharge diagnoses.

METHODS

We performed a descriptive cohort study of all patients assigned to a diagnostic package in the five EDs of the RSD (population 1,200,000 persons) between 1 April and 30 June 2013 (Figure 1).

The Danish healthcare system is tax-funded and provides free healthcare for all residents. All residents of Denmark are assigned a unique personal identification number at birth or immigration, which is used for all health contacts. This number permits unambiguous linkage between healthcare administrative registries [8]. Data were linked to data from the Danish National Patient Registry [9]. Appropriate diagnostic packages were defined as an acceptable standard and defined by a Delphi method based on the patient discharge diagnosis (from in-hospital care), see below.

Variables

The analysis was based on data on the following variables: assigned diagnostic package, patient discharge
diagnosis, hospital, gender, age, time of admission and discharge, length of stay, diagnostic package assigned, first documented discharge diagnosis, last documented discharge diagnosis (at hospital) according to the International Classification of Diseases (ICD)-10 index, and co-morbidity (Charlson Comorbidity Index) [10].

Acceptable standard procedure

We defined which diagnostic packages offered acceptable handling of patients who ended up with specific ICD-10 discharge diagnoses and used this as our acceptable standard.

As an example, a patient who ends up being discharged with pneumonia could be assumed to have received acceptable primarily diagnostic actions if a fever or dyspnoea package had been assigned, while a range of other packages such as trauma of extremity or psychosis would not have produced primarily acceptable diagnostic actions. Four of the authors are physicians, who work with acute patients and are specialists in internal medicine, infectious diseases or cardiology, while the fifth author is a specialist in nursing.

The acceptable standard was developed in a three-step modified Delphi procedure [11] in which:

– A list of all discharge diagnoses given in the inclusion period (n = 2,067) and of the diagnostic packages assigned (n = 40) was generated.

– Each of the five authors indicated which of the diagnostic packages would, in their opinion, have offered relevant primarily diagnostic actions for a patient with the given discharge diagnosis. More than one diagnostic package could be suggested. Project members were blinded to information about the other members’ choices.

– Association between a discharge diagnosis and a diagnostic package was established when a minimum of three project members considered
that a package was an acceptable choice for the diagnosis.

Each project member performed 4,304 such associations. For 85% of the cases, the association was considered acceptable by at least three, or inappropriate by five members. In the remaining 15% of associations, we discussed until a consensus was achieved (details can be obtained from the corresponding author).

Analyses

Age and length of stay are presented as medians (inter-quartile range (IQR)) and results concerning diagnostic packages are given as proportions (95% confidence
interval (CI) based on a binominal distribution) as appropriate. Given our expectation that patients’ chance of being assigned an acceptable diagnostic package would decrease with the complexity of their complaint and the duration of their admission, analyses were stratified by length of stay and co-morbidity (Charlson Comorbidity Index). All analyses were performed using Stata 13 software (StataCorp. 2013. Stata Statistical Software: Release 13. College Station, TX: StataCorp LP).

Ethical considerations

The study was considered a quality assurance project and was approved by the heads of the EDs, the hospital managements and by the Regional Council. No ethical approval was required. The study was registered with the Danish Data Protection Agency (No. 2008-58-0035).

Trial registration: The study was registered with the Danish Data Protection Agency (No. 2008-58-0035).
No further approval was required.

RESULTS

Population and distribution of diagnostic packages

We identified 17,694 patient contacts that had been assigned to a diagnostic package in the inclusion period.
A total of 17,531 of these contacts were validated as unique patient pathways. Cases involving redundant contacts within 24 hours (n = 141) were excluded as it
is not possible to separate cases of readmission within 24 hours. Likewise, children younger than 15 years of age (n = 288) (the diagnostic packages were not designed for children) were excluded, leaving a sample of 17,102 cases for descriptive analysis. Of these, 16,543 (96.7%) were identified in the Danish National Patient Registry, enabling validation for the key analyses concerning co-morbidity and association between assignments to diagnostic packages and discharge diagnoses (Figure 2).

Women constituted 52.2% (n = 8,925) of the included patients. The median age was 64 years (IQR: 44-77) and the median in-hospital length of stay was one day (IQR: 0-4).

The number of different discharge diagnoses used by EDs was 1.8; the corresponding number for hospital discharge was 2.0. All of the 40 described diagnostic packages were represented. Abdominal pain was the most frequently assigned diagnostic package (21%),
followed by airway symptoms (11%), neurologic disorder and chest pain (both 6%) (Table 1); 80% of all included patients (13,880) were covered by 14 diagnostic packages.

Association between discharge diagnoses and diagnostic packages

A total of 68% of the included patients had been assigned an acceptable diagnostic package (95% CI: 67.2-68.7). We found appropriate use of packages in more than 50% of cases in 30 diagnostic packages (Table 2). The analysis of the appropriateness of the diagnostic packages assigned found a 100% fit for the package uncooperative patient; however, this was used only four times. Among the more frequently used packages, appropriate choices were made in 84.7% of extremity trauma cases (n = 366), 82.4% of surgical abscess (n = 329) cases and 80.8% of airway symptom (n = 1,831) cases.

Age group, hospital, length of stay and co-morbidity

We found significant associations between age and assignment to an acceptable diagnostic package; younger patients were more likely than elderly patients to be offered an acceptable package (p < 0.001).

Where length of stay was 2-5 days, significantly more patients were assigned an acceptable diagnostic package compared with shorter or longer stays (p < 0.001). The studied hospitals showed no significant differences with respect to their success in assigning patients to acceptable pathways.

No co-morbidity was found in 47.7% of the included cases, whereas 31.5% were classified as 1-2 and 20.7% were classified as greater than or equal to 3 on the Charlson Comorbidity Index. We found no significant association between co-morbidity and assignment to an acceptable diagnostic package.

DISCUSSION

We found that all diagnostic packages were used, and approximately 80% of all acute pathways were covered by only 14 packages. Around 68% of the included patients were assigned an acceptable diagnostic package, significantly more among younger patients and when the length of stay was 2-5 days.

Abdominal pain was the most frequently assigned diagnostic package (21%), followed by airway symptoms (11%), neurologic disorder and chest pain (both 6%). Our findings hence partly corroborate those of an American study in which abdominal pain, chest pain and breathing difficulties were among the five most commonly coded chief complaints [12]. Furthermore, in a Finnish study classifying 89 complaint categories, the authors found that 7.6% concerned abdominal pain, 3.7% chest pain and 4.9% airway symptoms [13]; a Danish study assessing the pathway of 9,863 acute patients showed that 20% were assigned to packages for abdominal pain, 6% for chest pain and 7% for airway symptoms [7]. Others [14] found a 86% correlation between discharge diagnoses and medical assessment practice in a Scandinavian material. Thus, our result may represent an underestimation.

Some of the 40 described diagnostic packages were used infrequently (25 < 2%, of those 16 < 1%) and 79% of the in-hospital admissions were assigned to the 14 most frequently used diagnostic packages. This corroborates the conclusion of the aforementioned study, which shows that 75% of all acute admissions are covered by a mere 12 complaint categories [7].

Our findings have organisational and clinical implications. We have shown that it is possible to describe a number of diagnostic packages which can be used in the ED and lead to correct diagnoses. The most frequently used diagnostic packages had a high proportion of appropriateness, except for the package unspecified illness. However, several of the packages were used infrequently, and the number of packages should be reconsidered. Some of the packages might be important to keep, even if they are rarely used as they describe the diagnostic processes of life- or limb-threatening conditions.

Our results are limited by certain factors. We used discharge diagnosis as a basis for the acceptable standard defining an appropriate primarily diagnostic package. A number of the discharge diagnoses may have been inadequate, too general or too unspecific to enable a reasonably safe assessment in our acceptable standard procedure. The result may therefore be that we failed to identify an acceptable pathway. Further investigation this question would require an audit of patient records.

We categorised acceptable assignments to specific patient pathways based solely on our assessment of the association between discharge diagnosis and the primarily diagnostic packages. The primarily diagnostic packages are suggestions to the clinicians, and it was not ascertained whether the diagnostic actions recommended in the chosen package were actually performed or to which degree the diagnostic package provided extra information to the clinician or extra quality to the patients compared with the previous, less structured, clinical standard.

CONCLUSIONS

We found that 68% of the included patients were assigned an acceptable diagnostic package, and that about 80% of all acute pathways were covered by 14 diagnostic packages.

The diagnostic packages showing the highest proportion related to relevant discharge diagnoses are
trauma of extremity, surgical abscess, airway symptoms, abdominal pain, poisoning, pain in back and loins, pain and symptoms from urinary tract and blood glucose deviances, all of which recorded more than 75% match between discharge diagnoses and diagnostic package.

We suggest that the concept of acute diagnostic packages be further refined and tested.

Correspondence: Birgitte Nørgaard. E-mail: binorgaard@health.sdu.dk

Accepted: 18 March 2016

Conflicts of interest:Disclosure forms provided by the authors are available with the full text of this article at www.danmedj.dk

Acknowledgements: We would like to acknowledge the support received from the Region of Southern Denmark, Hospital Lillebaelt, the Hospital of Southern Jutland, the Hospital of South West Jutland, Svendborg Hospital and Odense University Hospital.

Referencer

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