Early-onset scoliosis (EOS) defined as scoliosis (Cobb angle > 10°) presenting before the age of ten  is a rare but often severe condition. It is well known that left untreated, EOS may lead to increased disability and potentially life-threatening conditions such as respiratory insufficiency and pulmonary hypertension and a reduced life expectancy . The aetiologies of EOS are idiopathic, neuromuscular, congenital and syndromic with a wide spectrum of underlying diagnoses .
The treatment goals are three-fold 1) preservation of thoracic growth including lung growth and pulmonary function, 2) preservation of quality of life and 3) correction of deformity .
Non-operative treatment consists of bracing and serial casting . However, patients with EOS due to an underlying neuromuscular syndrome usually do not respond favourably to bracing (radiographic progression) and serial casting may only postpone surgery for a limited amount time [4, 5].
The traditional growing rods (TGR) require distractions to be performed as open surgery in general anaesthesia every six months. It is unsurprising that the magnetically controlled growing rods (MCGR) have gained widespread use. The pain-free lengthenings are done every second to third month in the outpatient clinic using an external actuator placed on the skin of the patients (Figure 1). MCGR have been used as the surgical solution for EOS at our institution for the past decade. But MCGR use is not without complications. Some studies record the frequency of complications to reach 50% [6, 7].
The aim of this study was to report the results of primary MCGR implantation in a consecutive group of patients with EOS diagnosed and operated at Aalborg University Hospital from 2009 and onwards and with at least two years of follow-up with special regard to thoracic growth, deformity correction and complications.
Only patients without prior spine surgeries were included. All data were extracted from the electronic patient records (Clinical Suite from DXC. Technology, version 22.214.171.124) and the Picture Archiving and Communication System using the radiographic imaging viewer (EasyViz, 8.0.8-37el7.final). Data acquisition and measurements were all done by the same unbiased observer (first author). Sex, age, weight and date of the primary surgery were recorded along withspecific diagnoses, mobility (e.g., the ability to walk), survival, complications and rod exchanges. The following complications were recorded: No rod distraction before the rod had reached its full lengthening potential requiring rod exchange, rod malfunction (other than no distraction), rod breakage, screw breakage, screw loosening, infection, proximal junctional failure and distal junctional failure.
The height from T1-T12 and T1-S1 as well as the Risser Classification were measured on radiographs taken immediately before the primary surgery. The T1-T12 and T1-S1 height were measured again on the latest post-operative radiographs. The spinal height was measured as the perpendicular between two parallel lines passing through the centres of the chosen endplates. The Cobb angle and the thoracic kyphosis angle were measured pre- and immediately post-operatively and again on the latest post-operative radiographs. Rod size, level of instrumented vertebrae and number of anchors were recorded as noted in the procedure description and by analysing the immediate post-operative X-rays. Only the MAGEC system (Nuvasive inc., US) generation 2 was used. Two MCGR and pedicle screws anchors only were used in all cases (Figure 2).
All MCGRs were implanted from the thoracic to the lumbar part of the spine. One proximal and one distal incision were used in all cases and the rods were tunnelled between these two incisions. Interlaminar and/or posterolateral fusion with allograft was performed on the anchor levels after decortication. To place the pedicle screws correctly, O-arm 3-D scanning and navigation using the StealthStation S7/8 were used in all cases. A thoracolumbar orthosis was used for three months after the operation. Distraction was done every second to third month starting three months after implantation of the MCGR. The distraction-to-stall method of lengthening was used in all cases on both rods.
When a distraction force of approximately 250 Nm is obtained, the internal actuator automatically stops and a clunk is felt. The alternative is to base the amount of distraction on published growth charts – “tail-gating”. It was shown that the distraction-to stall method results in a satisfactory spinal height increase and produces results comparable to those of the tail-gating method . The patients had digital X-rays taken immediately before and after surgery and after each outpatient lengthening session. The number of lengthening or distraction sessions was counted, and the delta distraction of both rods was measured on the digital radiographs as described previously .
Statistical analysis was undertaken using base R (R version 4.02). Continous variables were expressed as mean ± standard deviation or median and range. Non-parametric analysis was performed using the Wilcoxon signed rank test. A p-value of < 0.05 was considered statistically significant. The Bonferroni correction for repeated measures was applied.
The study was approved by the local ethics board at Aalborg University Hospital. As this was a quality control study using retrospectively collected data, review and approval by the National Committee on Health Research Ethics were not required under Danish law.
Trial registration: not relevant.
Table 1 shows the patients demographics, Cobb angles and maximal kyphosis angles preoperatively, immediately after surgery and at the last follow-up. The specific diagnoses were five with cerebral palsy, one chromosomal abnormality, one myelomeningocele, one spinal muscular atrophy type 2, one giant axonal neuropathy (GAN), one POLG1 mutation (Leigh’s syndrome) and one Nemaline myopathy, two Prader Willi, one VACTERL syndrome, one Rett syndrome and one patient with multi-level congenital spinal anomalies. Eleven were non-walkers. The mean initial Cobb angle correction from preoperatively to immediately post-operatively was 67.7%, standard deviation (SD): ± 18.1%. At the last follow-up, this had decreased to a mean 60.2%, SD: ± 18.5%. The mean maximal kyphosis angle decreased from preoperatively to post-operatively by 40.2%, SD: ± 20.1% and to a mean 30.1%, SD: ± 27.4% at last follow-up.
Table 2 shows the total distraction in mm for the convex and concave rod and the number of distractions, T1-T12 height and T1-S1 height in cm preoperatively and at the last follow-up, follow-up time in years and the number of proximal and distal anchors. The mean increase in T1-T12 height from immediately preoperatively to the last follow-up was 51.3 mm SD ± 22.3 mm. The mean increase in T1-S1 height from immediately preoperatively to the last follow-up was 84.0 mm SD: ± 36.1 mm. The differences in Cobb angles and maximal kyphosis angles pre- and post-operatively and between preoperatively and the last follow-up were all significant with p-values ≤ 0.001. Likewise, the increases in the T1-T12 and T1-S1 heights from preoperatively to the last follow-up were all significant with p-values ≤ 0.001. The Bonferroni correction requires that all p-values are below 0.008.
We did not register any intraoperative complications. Three out the of the 15 patients had the complication “no rod distraction” on one of the rods before the rod had reached its full lengthening potential. The non-functioning rods were exchanged for new ones and the repeated lengthenings were continued. Mild-to-moderate metallosis around the rods was seen in all the three above-mentioned cases at surgery. One patient had deep wound infection and required reoperations with subsequent exchange of the rods. No other complications were recorded. Our total complication rate is 27% with a 7% infection rate. The revision rate per patient per year of follow-up was 0.07 (number of complications/number of patients/average follow-up time). Two patients had rod exchange because the rods had reached their full lengthening potential, making it a planned revision. In six patients at or near maturity, it was decided to stop lengthenings. These six patients will be followed for signs of rod breakage and screw loosening, etc. and controlled in the outpatient clinic annually. So far, none of these patients have experienced any complications. One patient at or near maturity had the MCGR removed and underwent final scoliosis surgery without any complications. One death was recorded in the observation period caused by the severe underlying disease.
Patients with EOS constitute a very diverse group, which is also evident from the present case series. Neuromuscular diseases were the main cause of EOS in the present case series. Several patients had severely compromised pulmonary function and were either using some kind of respiratory support or had a story of repeated bronchopulmonary infections. Five of the patients had progressive neuromuscular disease. Most of the patients would not have tolerated the repeated surgeries, which are an inevitable part of TGR treatment. Repeated spine surgeries in children have also been shown to have adverse psychological effects .
The deformity correction in the present series was satisfactory and supprior to those reported in most other case series [3, 6, 11-14]. The deformity correction is explained by a high number of patients with neuromuscular disease and hypotonus (collapsing spine), the use of double rods and the fact that only primary cases were included. The decrease from immediately post-operatively to last follow-up is a constant part of the treatment with MCGRs and is an almost universal fact . The mean correction of the maximal thoracic kyphosis angle in the present study must be considered adequate. It is inevitable that some correction will be lost simply due to the distractions which tend to increase the thoracic kyphosis. We did not register any cases of proximal or distal junctional failure. We took great care to bend the upper part of the rods into a configuration resembling the high thoracic kyphosis present and not to force a reduction of this part of the curve.
A T1-T12 height of 22 cm is considered adequate . All but two of the patients reached this limit – and the last two of the patients are still undergoing repeated distractions. A T1-S1 height of 45 cm at skeletal maturity is considered normal. However, given the patients in the current case series, it would be a mistake to believe that they can reach this value of normality. The total amount of distraction of the MCGRs averaged approximately 33 mm or on average approximately 9 mm annually. Without doubt the correction of the Cobb angle and the kyphosis angle has contributed to the increase in T1-T12 and T1-S1 height. The distraction capability depends on several factors – the most common being mechanical malfunction of the rod. As the MCGR is capable of delivering a force of only 250 Nm, the weight of the patient is probably also a factor.
The number of complications compares favourably with other case series [3, 6, 7, 11-14]. We attribute this to the use of pedicle screws as anchors, to the use of the O-arm/navigation, the use of a thoracolumbar brace for three months, the exclusion of conversion cases from TGR and the high number of anchors. It is a fact that after a certain number of distractions, the MCGR will stop functioning and will often do so before the MCGR has reached the full 48 mm of distraction. However, the “law of diminishing returns” may be counteracted with the exchange of the MCGR  – a fact we can corroborate.
Two of the patients cannot strictly be classified as EOS patients as they were 12 years of age at surgery. The first case was the patient with Retts syndrome, epilepsy and severely compromised respiratory function. She has only recently entered puberty (18 years old). The second was the patient with GAN. He was a candidate for intrathecal injections with a vector-mediated therapy for GAN. In the first case, we wanted the surgery to be as minimal as possible and in the second case ordinary scoliosis surgery would have excluded the possibility of gene therapy as it requires intrathecal injection at the level of the third lumbar vertebra.
For the same reasons, we opted to leave in the rods in six cases to avoid further surgery in these very frail patients with severely compromised respiratory function and a multitude of other diseases. Currently, this has not resulted in additional surgeries. Our normal strategy would be instrumented fusion after stopping distractions.
The limitations of the current consecutive case series are obviously the small number of patients and the retrospective design. However, this is not unusual as EOS is a rare disease with diverse aetiologies. The number of cases in other case series falls in the 15-44 range [3, 6, 7, 11-14]. The use of MCGR was first described in 2012 in a case series with five patients . We are unable to report any quality-of-life measures. In most cases, we would have to rely on a proxy judgement of the quality of life because of the severity of the underlying diseases in our case series, and the usual quality-of-life measures used for EOS patients are not validated for use in Danish language. However, a large multicentre study comparing MCGR with TGR has reported improvements in quality-of-life measures and concluded that MCGR with a reduced number of surgeries has better psychosocial effects .
Based on the present findings, our conclusion is that the MCGR may reduce the deformity and support thoracic and pulmonary growth with no need for repeated surgeries. The number of complications in the present series was low compared with the literature with an average of 0.07 complications per year per patient or a total complication rate of 27%.
Correspondence Charlotte Sommer Meyer. E-mail. email@example.comAccepted 3 February 2022Conflicts of interest Potential conflicts of interest have been declared. Disclosure forms provided by the authors are available with the article at ugeskriftet.dk/dmjReferences can be found with the article at ugeskriftet.dk/dmjCite this as Dan Med J 2022;69(4):A08210627
Helenius IJ. Standard and magnetically controlled growing rods for the treatment of early onset scoliosis. Ann Transl Med. 2020;8(2):26.
Pehrsson K, Larsson S, Oden A et al. Long term follow-up of patients with untreated scoliosis. Spine J. 1992;17(9):1091-6.
Ridderbusch K, Rupprecht M, Kunkel P et al. Preliminary results of magnetically controlled growing rods for early onset scoliosis. J Pediatr Orthop. 2017;37(8):e575-e580
Fletcher ND, McClung A, Rathjen KE et al. Serial casting as a delay tactic in the treatment of moderate-to-severe early-onset scoliosis. J Pediatr Orthop. 2012;32(7):664-71.
LaValva S, Adams A, MacAlpine E et al. Serial casting in neuromuscular and syndromic early-onset scoliosis (EOS) can delay surgery over 2 years. J Pediatr Orthop. 2020;40(8):e772-e779.
Obid P, Yiu K, Cheung K et al. Magnetically controlled growing rods in early onset scoliosis: Radiological results, outcome, and complications in a series of 22 patients. Arch Orthop Trauma Surg. 2021;141(7):1163-74.
Wu A-M, Cheung JPY, Cheung KMC et al. Minimum 2-year experience with magnetically controlled growing rods for the treatment of early-onset scoliosis: a systematic review. Asian Spine J. 2019;13(4):682-93.
Dragsted C, Fruergaard S, Jain MJ et al. Distraction-to-stall versus targeted distraction in magnetically controlled growing rods. J Pediatr Orthop. 2020;40(9):e811-817.
Bye B, Graham CK, Robbins C et al. Level of experience does not influence the accuracy of radiographic and ultrasound measurements of magnetically controlled growing rod distractions. J Pediatr Orthop. 2020;40(5):e341-e345.
Flynn JM, Matsumoto H, Torres F et al. Psychological dysfunction in children who require repetitive surgery for early onset scoliosis. J Pediatr Orthop. 2012;32(6):594-9.
Abdelaal A, Munigangalah S, Trivedi J et al. Magnetically controlled growing rods in the treatment of early onset scoliosis: a single centre experience of 44 patients with mean follow-up of 4.1 years. Bone Jt Open. 2020;1(7):405-14.
Lampe LP, Bövingloh AS, Gosheger G et al. Magnetically controlled growing rods in treatment of early-onset scoliosis. A single center study with a minimum of 2-year-follow up and preliminary results after converting surgery. Spine (Phila Pa 1976). 2019;44(17):1201-10.
Kliliçaslan ÖF, Tokgöz AM, Bütün S et al. Management and results of early-onset scoliosis with dual magnetically controlled growing rods: additional preliminary results of spinal fusion. Jt Dis relat Surg. 2021;32(2):478-88.
Studer D, Heidt C, Büchler P et al. Treatment of early onset spinal deformities with magnetically controlled growing rods: a single centre experience of 30 cases. J Child Orthop. 2019;13(2):196-205.
Canavese F, Dimeglio A. Normal and abnormal spine and thoracic cage development. World J Orthop. 2013;4(4):167-74.
Cheung JPY, Bow C, Cheung KMC. “Law of temporary diminishing distraction gains”: the phenomenon of temporary diminished distraction lengths with magnetically controlled growing rods that is reverted with rod exchange. Global Spine J. (online 17 Aug 2020).
Cheung KMC, Cheung JPY, Samartzis D et al. Magnetically controlled growing rods for severe spinal curvature in young children: a prospective case series. Lancet. 2012;379(9830):1967-74.
Matsumoto H, Skaggs DL, Akbarnia BA et al. Comparing health-related quality of life and burden of care between early-onset scoliosis patients treated with magnetically controlled growing rods and traditional growing rods: a multicenter study. Spine Deform. 2021;9(1):239-45.