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Akut induceret diabetes mellitus hos en patient i behandling for metastaserende malignt melanom

Malignt melanom. (Foto: Georg Authried, Dermatologisk Afdeling, Odense Universitetshospital).
Line Bisgaard Jørgensen & Knud Yderstræde Endokrinologisk Afdeling M, Odense Universitetshospital Ugeskr Læger 2017;179:V03170188
Ugeskr Læger 2017;179:V03170188
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Acutely induced diabetes mellitus in a 63-year-old female after treatment with ipilimumab for metastatic melanoma
Immune checkpoint inhibitors have improved survival rate in patients with advanced melanoma, but also have the potential to induce several adverse events. We report on a 63-year-old woman who had advanced melanoma and was admitted with diabetic ketoacidosis, which had occurred upon treatment with ipilimumab. On admission, the C-peptide level was low, and the HbA1c concentration was 50 mmol/l indicating a rapid onset of the disease. The patient had also been diagnosed with thyroiditis. Diabetes mellitus is a rare and serious side effect of treatment with ipilimumab, and we recommend being aware of this due to the rapid course.
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