Thorsten Kamlarczyk Rasmussen, Else Vestbo, Klaus Krogh, Páll Karlsson, Troels Staehelin Jensen, Henning Andersen & Astrid Juhl Terkelsen

Ugeskr Læger 2021;183:V09200651

Treatment-induced neuropathy of diabetes is an iatrogenic acute painful sensory and autonomic neuropathy. The condition is caused by rapid downregulation of blood glucose after a long period of hyperglycaemia. In this case report, a 43-year-old man with Type 1 diabetes and severe metabolic dysregulation had downregulated his blood glucose level with 3.8% over ten weeks through optimised insulin treatment and weight loss. He developed severe neuropathic pain due to small fiber neuropathy and neurogenic autonomic dysfunction with erectile dysfunction, urine retention and cardiovagal and enteric dysfunction.