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Donorsøgning til hæmatopoietisk stamcelletransplantation

Forfatter(e)

Helle Bruunsgaard1, 2 & Anne Werner Hauge1

1) Sektion for Transplantationsimmunologi og Danske Stamcelledonorer Øst, Klinisk Immunologisk Afdeling, Diagnostisk Center, Rigshospitalet, 2) Institut for Klinisk Medicin, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet

Ugeskr Læger 2020;182:V08200585

Reference: 
UgeskrLæger 2020;182:V08200585
Donor search for haematopoietic stem cell transplantation

Ugeskr Læger 2020;182:V08200585

Allogeneic haematopoietic stem cell transplantation is a clinical example of precision medicine, as one individual donor is selected for one individual patient based on genetic findings in the human leukocyte antigen (HLA) system. Unrelated donor search for Danish patients is based on an international collaboration between global registries hosting more than 37 million potential donors worldwide for patients in need. The implementation of next-generation sequencing technologies has been a revolution in donor registry typing due to more precise, detailed and cheaper HLA analyses, which is discussed in this review.

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