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Elektrokemoterapi til behandling af kutane metastaser

Hanne Falk1, Louise Wichmann Matthiessen1, Karin Dahlstrøm2 & Julie Gehl1 1) Onkologisk Afdeling, Herlev Hospital 2) Plastikkirurgisk Afdeling, Herlev Hospital Ugeskr Læger 2015;177:V12140666
Ugeskr Læger 2015;177:V12140666
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Electrochemotherapy for treatment of cutaneous metastases
Cutaneous metastases occur in up to 9% of all patients with cancer and may cause discomfort and stigmatization. Electro­chemotherapy is a local treatment using electric pulses to permeabilize cell membranes, enabling chemotherapy, such as bleomycin, to enter the cells and increase the cytotoxic effect by at least 300-fold. Electrochemotherapy is an efficient, once only treatment for cutaneous metastases with an objective response of 62-99%. Electrochemotherapy can reduce discomfort such as ulceration, oozing, bleeding and pain. Adverse events depend on the size of treatment area, but are very limited.
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