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Elektroporation, elektrokemoterapi, calciumelektroporation og genterapi som led i kræftbehandlingen

Forfatter(e)
Julie Gehl1, 2 & Stine Krog Frandsen1
1) Center for Experimental Drug and Gene Electrotransfer, Klinisk Onkologisk Afdeling og Palliative Enheder, Sjællands Universitetshospital, Roskilde 2) Institut for Klinisk Medicin, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet

Ugeskr Læger 2019;181:V08190461
Reference: 
Ugeskr Læger 2019;181:V08190461
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Julie Gehl & Stine Krog Frandsen:

Electroporation-based therapies in the treatment of cancer

Ugeskr Læger 2019;181:V08190461

Electroporation is a method to permeabilise cell membranes. It can be categorised as 1) reversible electroporation in order to increase the uptake of therapeutic molecules such as chemotherapy, calcium, or DNA, or 2) irreversible electroporation where the cell is permeabilised extensively, and both methods are used in cancer treatment. The treatment is brief and is performed under local or general anaesthesia. Electrochemotherapy and irreversible electroporation have proven efficient across different cancer histologies. This review describes the background for electroporation-based treatment, methods, and results of treatment.

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