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Er det vaskulitis i centralnervesystemet?

Forfatter(e)
Reservelæge Lisbeth Rosholm Comstedt & professor Peter Junker Odense Universitetshospital, Reumatologisk Afdeling
Reference: 
Ugeskr Læger 2008;170(25):2256
Blad nummer: 
Sidetal: 
2256
Summary Is it CNS vasculitis? - Essential thrombocythaemia with a normal platelet count Ugeskr Læger 2008;170(25):2256 A 58-year old woman was admitted with transient ischaemic attacks. Cerebral MRI was compatible with vasculitis. Blood chemistry was normal, but after 9 months she developed thombocytosis above 600 × 109 /l. A bone marrow biopsy showed myeloproliferative changes. Further investigations revealed over-expression of the polycythaemia rubra vera-1 gene and she carried the Janus Kinase-2 mutation, V617F. This case emphasizes that a myeloproliferative disorder should be considered in patients with unexplained ischemic CNS manifestations, even if blood counts are normal.
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