Fjerdegenerations-p-piller medfører større risiko for venøs tromboemboli end andengenerations-p-piller
Ugeskr Læger 2013;175(20):1404-1408
Summary Marlene Lunddal Krogh & Birgitte Klindt Poulsen: Fourth generation oral contraceptives are associated with a higher risk of venous thromboembolism compared to second generation Ugeskr Laeger 2013;175:1404-1408 It has been widely discussed whether fourth generation oral contraceptives (OC) are associated with a higher risk of venous thromboembolism (VTE) compared to second generation. Lack of randomized controlled trials, methodological problems and inconsistent criteria for the VTE event has led to conflicting results. Three newly published studies utilising improved methodology show that fourth generation OC are associated with an increased risk of VTE compared to second generation OC. This knowledge has led to a change in recommendation of the first drug of choice, which is now second generation OC.