Ugeskr Læger 2014;176:V08130517
Genetic tests are available but they are based on incomplete data
Direct-to-consumer genome-wide profiling is a rising phenomenon. The risk estimates given by these genetic tests are based on scientifically true but incomplete data. The consumers expect to be given personal individualized risk estimates for multifactorial diseases, and they are, but the risk estimates are only based on the small fraction of hereditability that we are able to explain by common genetic markers, and therefore the dimensions of other contributing factors need to be understood before one can realise the validity of a risk estimate for a multifactorial disease.