Ugeskr Læger 2014;176:V06140347
The genome and ageing
Lifespan, longevity and healthy aging are complex phenotypes, and unravelling of the genetic background has been challenging. Excess of advantageous gene variants seems to be of more importance for longevity than absence of known disease-susceptibility genes. Animal studies have pointed to candidate pathways related to ageing, but only a few genes have repeatedly been associated to human lifespan. Research into the genetic contribution to a long and healthy life is currently focusing on epigenetic phenomena and the importance of rare variants in families enriched for longevity.