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Klonal hæmatopoiese som mulig risikofaktor for hjerte-kar-sygdom

Forfatter(e)

Peter Riis Hansen1, 2

Hjertemedicinsk Afdeling, Herlev-Gentofte Hospital
2) Institut for Klinisk Medicin, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet

Ugeskr Læger 2020;182:V04200299

Reference: 
Ugeskr Læger 2020;182:V04200299
Blad nummer: 
Clonal haematopoiesis is possibly a risk factor for cardiovascular disease

Peter Riis Hansen

Ugeskr Læger 2020;182:V04200299

The ageing process is associated with somatic mutations in haematopoietic stem cells, which can lead to clonal haematopoiesis. Recently, clonal haematopoiesis has emerged as a risk factor for cardiovascular disease, and the underlying mechanisms likely involve heightened inflammatory responses in leukocytes derived from mutated clones. This review outlines the concept of clonal haematopoiesis of indeterminate potential and summarises epidemiological and experimental evidence, which support the notion that clonal haematopoiesis-mediated inflammation contributes to cardiovascular disease.

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