Content area

|
|

Kombinationsbehandling med fluconazol og andre QTc-forlængende lægemidler forlænger QTc- intervallet

Forfatter(e)
Tina Buch & Stig Ejdrup Andersen Klinisk Farmakologisk Enhed, Roskilde Sygehus Ugeskr Læger 2015;177:V04150371
Reference: 
Ugeskr Læger 2015;177:V04150371
Blad nummer: 
Sidetal: 
2-3
Combination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval.
Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.
Du skal være logget ind for at læse denne artikel
Log ind

Right side

af Anna Inger Roe Rasmussen | 02/12
18 kommentarer
af Troels Krogh Nielsen | 30/11
7 kommentarer
af Flemming Juul Hansen | 29/11
1 Kommentar
af Jacob Peter Tolstrup | 27/11
4 kommentarer
af Mats Lindberg | 26/11
1 Kommentar