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Loperamid misbrugt for at opnå euforiserende effekt hos en ung kvinde

Forfatter(e)

Signe Fiil1, Terese Matthesen Kamronn2, 3, Tonny Studsgaard Petersen4 & Signe Livbjerg2, 3

1) Rusmiddelcenter Aarhus, Sociallægeinstitutionen, Aarhus Kommune

2) Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital

3) Klinisk Farmakologisk Afdeling, Aalborg Universitetshospital

4) Klinisk Farmakologisk Afdeling, Bispebjerg og Frederiksberg Hospital

UgeskrLæger 2020;182:V11190650

Reference: 
UgeskrLæger 2020;182:V11190650
A young woman’s loperamide abuse for the achievement of euphoric effect

Signe Fiil, Terese Matthesen Kamronn, Tonny Studsgaard Petersen & Signe Livbjerg:

Ugeskr Læger 2020;182:V11190650

Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.

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