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Magnesiumsulfat nedsætter risikoen for cerebral parese efter præterm fødsel

Forfatter(e)

Hanne Trap Wolf1, Tine Brink Henriksen2, Mads Langager Larsen3, Anja Pinborg4, Hanne Kristine Hegaard5, Jesper Sune Brok3 & Lene Drasbek Huusom6

1) Gynækologisk-Obstetrisk Afdeling, Hvidovre Hospital, 2) Børn og Unge, Aarhus Universitetshospital, 3) BørneUngeKlinikken, Rigshospitalet, 4) Fertilitetsklinikken, Rigshospitalet, 5) Obstetrisk Klinik, Rigshospitalet, 6) Afdeling for Kvindesygdomme, Graviditet og Fødsler, Herlev Hospital

Ugeskr Læger 2020;182:V06200441

Reference: 
UgeskrLæger 2020;182:V06200441
Magnesium sulphate treatment decreases the risk of cerebral palsy after preterm birth

Hanne Trap Wolf, Tine Brink Henriksen, Mads Langager Larsen, Anja Pinborg, Hanne Kristine Hegaard, Jesper Sune Brok & Lene Drasbek Huusom

Ugeskr Læger 2020;182:V06200441

Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.

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