Oona Nørgaard van Achter & Selvavathany Sivagurunathan

Ugeskr Læger 2020;182:V09200630

Neuroleptic malignant syndrome (NMS) is a rare but severe complication to antipsychotic treatment. Both first-generation and second-generation antipsychotics can induce NMS. This is a case report of NMS induced by second-generation antipsychotic treatment with aripiprazole causing symptoms of rigidity, altered mental status, diaphoresis and creatine kinase elevation. A 27-year-old man was admitted to an ICU and underwent ECT treatment on day ten, 11 and 12 after presentation of the symptoms. There was significant symptom improvement after ECT treatment and full recovery after two weeks.