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Methotrexat kan anvendes som steroidbesparendebehandling af svær astma

Astmapatient i anfald.
Forfatter(e)
Malene Knarborg1, Ole Hilberg1 & Ronald Dahl2 1) Lungemedicinsk Afdeling, Aarhus Universitetshospital 2) Allergicentret, Odense Universitetshospital Ugeskr Læger 2014;176:V10130598
Reference: 
Ugeskr Læger 2014;176:V10130598
Blad nummer: 
Sidetal: 
1159-1163
Methotrexate may be a useful corticosteroid reducing treatment of severe asthma
Asthma is a chronic airway disease affecting many people worldwide. Less than 1% suffers from difficult-to-treat asthma and requires systemic corticosteroid treatment to achieve symptom control. The therapeutic options for these patients are limited and often we have to accept a lesser degree of symptom control. Methotrexate has been evaluated in 13 studies, where the mean corticosteroid dose reduction was 35%. Despite the adverse effects, we find that methotrexate may be a useful treatment of severe asthma in certain patients under close observation.
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