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Myeloproliferativ cancer og kronisk inflammatorisk tarmsygdom

Forfatter(e)

Heidi Hesselø1, Marie Bak1, Trine Boysen2, 3, Peter Bytzer3 & Hans Carl Hasselbalch1

1) Hæmatologisk Afdeling, Sjællands Universitetshospital, Roskilde, 2) Gastroenheden, Hvidovre Hospital, 3) Medicinsk Afdeling, Sjællands Universitetshospital, Køge

Ugeskr Læger 2020;182:V09190483

Reference: 
UgeskrLæger 2020;182:V09190483
Myeloproliferative neoplasms and chronic inflammatory bowel disease

Heidi Hesselø, Marie Bak, Trine Boysen, Peter Bytzer & Hans Carl Hasselbalch:

Ugeskr Læger 2020;182:V09190483

Studies have suggested a possible association between inflammatory bowel disease (IBD) and the Philadelphia-negative chronic myeloproliferative neoplasms (MPNs). The mechanisms behind this association have not been investigated yet, but in this review, we find it most likely to involve complex interactions between genetic, treatment-related and inflammation- and immune-mediated factors. When patients with IBD present with persistent leukocytosis and/or thrombocytosis, it may reflect concomitant MPN, and early detection and treatment of MPNs may prevent some of the complications related to these diseases.

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