Kathrine Balslev Skovmøller & Anette Bygum:
When drugs induce cutaneous lupus erythematosus
Ugeskr Læger 2018;180:V04180277
Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. There are no diagnostic criteria, yet detection of anti-Ro/SSA antibodies combined with erosive/bullous or erythema multiforme/toxic epidermal necrolysis-like lesions, and widespread skin rash seem to be indicative of DI-SCLE. The most common drugs involved are proton pump inhibitors, terbinafine, thiazides and chemotherapeutics.