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Ny test til diagnostik af tuberkulose

Forfatter(e)
Overlæge Pernille Ravn, reservelæge Michala Vaaben Rose, reservelæge Bolette Søborg & overlæge Åse Bengård Andersen Herlev Hospital, Infektionsmedicinsk Enhed, Medicinsk Afdeling O 107, Teule Hospital, Børneafdelingen, Tanga Tanzania, Statens Serum Institut, Mykobakteriologisk Laboratorium, og Rigshospitalet, Epidemiafdeling M
Reference: 
Ugeskr Læger 2009;171(37):2635-2639
Blad nummer: 
Sidetal: 
2635-2639
Summary New diagnostic test for tuberculosis Ugeskr Læger 2009;171(37):2635-2639 The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M.tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M.avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
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