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Opioider mod refraktær dyspnø i palliativ fase

Forfatter(e)

Birgit Aabom1, Elisabeth Bendstrup2, Per Sjøgren3, Anders Løkke4, Saher Burhan Shaker5, Torgny Wilcke5, Bodil Abild Jespersen6, Ole Hilberg4 & Kristoffer Marsaa7

1) Klinisk Onkologi og Palliative Enheder, Sjællands Universitetshospital Roskilde 2) Lungemedicinsk Afdeling, Aarhus Universitetshospital, 3) Palliativt Afsnit, Onkologisk Klinik, Rigshospitalet, 4) Lungemedicinsk Afdeling, Sygehus Lillebælt, 5) Lungemedicinsk Afdeling, Gentofte Hospital, 6) Enhed for Lindrende Behandling, Aarhus Universitetshospital, 7) Afdeling for Lindrende Behandling, Herlev Hospital

Ugeskr Læger 2020;182:V04200225

Reference: 
Ugeskr Læger 2020;182:V04200225
Opioids for refractory dyspnoea in palliation

Birgit Aabom, Elisabeth Bendstrup, Per Sjøgren, Anders Løkke, Saher Burhan Shaker, Torgny Wilcke, Bodil Abild Jespersen, Ole Hilberg & Kristoffer Marsaa

Ugeskr Læger 2020;182:V04200225

Dyspnoea is cardinal symptom in chronic obstructive lung disease and common in palliative phases of cancer and other chronic medical diseases. Low-dose opioids is frequently used off-label. This review examines the evidence and safety as well as administration forms and pharmacokinetics using low dose opioids for dyspnoea. Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.

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