Content area

|
|

Osteoklastfunktionen reguleres af naboosteoblaster

Forfatter(e)
Thor Ueland, Jens Bollerslev & Leif Mosekilde
Reference: 
Ugeskr Læger 2002;164(27): 3526-30.
Blad nummer: 
Sidetal: 
30.- 3526
Summary Osteoclast function is regulated by neighbouring osteoblasts: osteoprotegerin, RANK, and RANK ligand constitute a unique regulatory system for bone resorption with important pathophysiological and therapeutic aspects. Ugeskr Læger 2002; 164: 3526-30. Maturation of macrophages to osteoclasts requires the presence of marrow stromal cells or osteoblasts. Most calci- tropic hormones act indirectly on osteoclasts through receptors on neighbouring osteoblasts. The discovery of osteoprotegerin (OPG), the receptor activator of nuclear factor-kb ligand (RANKL), and its receptor (RANK) has elucidated these phenomena. It appears that osteoclast differentiation, activity, and survival are regulated by the proportion of inhibiting OPG to stimulating RANKL. OPG and RANKL are produced by osteoblasts, whereas RANK is located to the osteoclasts. Treatment with OPG inhibits bone resorption in postmenopausal women. Mutations in the system may be responsible for focal skeletal disorders. The discovery opens up for new treatment opportunities in postmenopausal and steroid-induced osteoporosis, Paget's disease, hypercalcaemia, and rheumatoid arthritis.
Du skal være logget ind for at læse denne artikel
Log ind

Right side

af Susanne Mejlby Nielsen | 06/08
4 kommentarer
af Gunvor Kramshøj Larsen | 04/08
28 kommentarer
af Jette Birgitte Lehnsbo Korsgaard | 03/08
2 kommentarer
af Olaf Bjarne Paulson | 03/08
1 Kommentar
af Hanne Hulgaard | 02/08
4 kommentarer
af Christian Stefan Legind | 28/07
2 kommentarer
af Connie Lærkholm Hansen | 23/07
1 Kommentar
af Lene Heise Garvey | 23/07
4 kommentarer
af Peter Tagmose Thomsen | 20/07
1 Kommentar