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Oxygen under tryk som behandling

Forfatter(e)

Ole Hyldegaard & Morten Hedetoft

Anæstesi- og Operationsklinikken, Trykkammeret 4092, Hoved-Orto-Centret, Rigshospitalet

Ugeskr Læger 2020;182:V06200463

Reference: 
UgeskrLæger 2020;182:V06200463
Blad nummer: 
Hyperbaric oxygen therapy

Ole Hyldegaard & Morten Hedetoft

Ugeskr Læger 2020;182:V06200463

Hypoxia triggers hypoxia-inducible factor (HIF). Not only hypoxia triggers downstream HIF target genes for transcription, as intermittent hyperoxia also possesses similar capabilities, suggesting that fluctuations in oxygen availability may be equally important for inducing HIF transcription. This review describes some of the mechanisms, whereby intermittent hyperbaric hyperoxia may explain some of the observations during hyperbaric oxygen therapy such as enhanced wound healing, angiogenesis and tissue healing, and concludes that oxidative stress enhances certain antibiotics in infection control.

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