Camilla Gaarsdal Uhrbrand, Kristian D. Friesgaard, Lone D. Brix, Jytte F. Møller & Lone Nikolajsen
Ugeskr Læger 2020;182:V02200092
Methadone is an opioid with several desirable pharmacological features, including a long elimination half-life. Several studies have suggested that a single intraoperative dose reduces post-operative pain and opioid consumption. In this review, we summarise the current knowledge of intraoperative methadone for the treatment of post-operative pain and propose recommendations for clinical use and future research.