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Posterior reversibel encefalopati efter behandling af malignt lymfom

Forfatter(e)
Rasmus Heje Thomsen1, Kristine Zakarian2 & Per Boye Hansen1 1) Hæmatologisk Afdeling, Roskilde Sygehus 2) Radiologisk Afdeling, Roskilde Sygehus Ugeskr Læger 2015;177:V03150236
Reference: 
Ugeskr Læger 2015;177:V03150236
Blad nummer: 
Sidetal: 
2-3
Malignant lymphoma complicated with posterior reversible encephalopathy
We present a 56-year-old woman who received chemotherapy for relapsed diffuse large B-cell lymphoma and developed posterior reversible encephalopathy syndrome (PRES) with generalized seizures 27 days after treatment with rituximab, ifosfamide, carboplatin and etoposide (R-ICE). The patient had moderate renal impairment (eGFR > 30 ml/min) and a normal blood pressure. PRES was confirmed by MRI, which showed oedema of the occipital, parietal and frontal lobes. A control MRI after four weeks showed full remission. To our knowledge this is the first published case of R-ICE causing PRES.
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