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Radium-223 behandling af knoglemetastaser ved kastrationsrefraktær prostatacancer

Forfatter(e)
Jann Mortensen & Liselotte Højgaard Klinik for Klinisk Fysiologi, Nuklearmedicin & PET, Diagnostisk Center Rigshospitalet Ugeskr Læger 2014;176:V04130224
Reference: 
Ugeskr Læger 2014;176:V04130224
Blad nummer: 
Sidetal: 
1399-1402
Radium-223 treatment of bone metastases from castration-resistant prostate cancer
The alpha emitter Radium-223 (223Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symp­toms. Intravenously administered 223Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.
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