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Samspillet mellem mikrobiota og immunsystemet ved kolorektal cancer

Forfatter(e)
Hans Raskov1, Thomas Bjarnsholt2, Mahdi Alamili3, Kasper Nørskov Kragh2 & Ismail Gögenur4
1) Center for Surgical Science, Sjællands Universitetshospital, Køge 2) Costerton Biofilm Center, Københavns Universitet 3) Gastroenheden, Hvidovre Hospital 4) Kirurgisk Afdeling, Sjællands Universitetshospital, Køge

Ugeskr Læger 2018;180:V04180253
Reference: 
Ugeskr Læger 2018;180:V04180253
Blad nummer: 

Hans Raskov, Thomas Bjarnsholt, Mahdi Alamili,
Kasper Nørskov Kragh & Ismail Gögenur:

Interaction between microbiota and immune system in colorectal cancer

Ugeskr Læger 2018;180:V04180253

In vivo- and in vitro research accumulate mounting evidence, that the interaction between the colorectal microbiota and the immune system plays an important role in the development and progression of colorectal cancer and for the treatment outcomes. In future, modulation of the microbiota and immune system will, by all accounts, become important targets for prevention and treatment of colorectal cancer. In this review, we summarise current knowledge on bacterial drivers, biofilm formation, colon cancer sidedness and oncological treatment of colorectal cancer including the use of checkpoint inhibitors.

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